Autophagy Biology And Diseases

Autophagy  Biology and Diseases PDF
Author: Weidong Le
Publisher: Springer Nature
ISBN: 9811542724
Size: 60.25 MB
Format: PDF
Category : Medical
Languages : en
Pages : 736
View: 3897

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Autophagy Biology And Diseases

by Weidong Le, Autophagy Biology And Diseases Books available in PDF, EPUB, Mobi Format. Download Autophagy Biology And Diseases books, This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine


Autophagy Biology And Diseases

Autophagy  Biology and Diseases PDF
Author: Zheng-Hong Qin
Publisher: Springer Nature
ISBN: 9811506027
Size: 67.26 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 727
View: 5215

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Autophagy Biology And Diseases

by Zheng-Hong Qin, Autophagy Biology And Diseases Books available in PDF, EPUB, Mobi Format. Download Autophagy Biology And Diseases books, This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.


Autophagy In Health And Disease

Autophagy in Health and Disease PDF
Author: Roberta A. Gottlieb
Publisher: Academic Press
ISBN: 0123851025
Size: 46.14 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 240
View: 4908

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Autophagy In Health And Disease

by Roberta A. Gottlieb, Autophagy In Health And Disease Books available in PDF, EPUB, Mobi Format. Download Autophagy In Health And Disease books, Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables


Autophagy In Disease And Clinical Applications

Autophagy in Disease and Clinical Applications PDF
Author: Daniel Klionsky
Publisher: Academic Press
ISBN: 9780080958484
Size: 57.53 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 536
View: 7524

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Autophagy In Disease And Clinical Applications

by Daniel Klionsky, Autophagy In Disease And Clinical Applications Books available in PDF, EPUB, Mobi Format. Download Autophagy In Disease And Clinical Applications books, The third and final installment of Daniel J. Klionsky's new three-volume treatment of autophagy, this volume focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. Edited by one of the leading authorities in the field, this volume and its companion volumes, Autophagy: Lower Eukaryotes and Autophagy in Mammalian Systems, provide a comprehensive overview of the techniques involved in studying autophagy in eukaryotes and simple animal systems, mammalian cells and non-human animals, and humans. Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning in the cell is called autophagy – literally self-eating. In the future, research in this field will help to design clinical approaches that can turn on autophagy and halt tumor growth. * Provides an overview of autophagy in regards to humans, specifically regarding disease connections and clinical samples. * Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture *Presents reliable methods that, in this relatively new field, allow the reader to find appropriate techniques to identify, monitor, and quantify autophagic processes


Autophagy Of The Nervous System

Autophagy of the Nervous System PDF
Author: Zhenyu Yue
Publisher: World Scientific
ISBN: 981444068X
Size: 48.83 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 440
View: 561

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Autophagy Of The Nervous System

by Zhenyu Yue, Autophagy Of The Nervous System Books available in PDF, EPUB, Mobi Format. Download Autophagy Of The Nervous System books, What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy. Contents:Neuronal Autophagy: Cellular Process and Regulation:The Cellular Process of Autophagy and Control of Autophagy in Neurons (Nicole C McKnight, Noboru Mizushima and Zhenyu Yue)Autophagosome Maturation, Endocytosis and Neurodegenerative Disease (Ai Yamamoto and Anne Simonsen)Cross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy (Serhiy Pankiv and Terje Johansen)Chaperone-Mediated Autophagy (CMA) in Neurons (Maria Xilouri, Hsiao-Yu Peng and Leonidas Stefanis)Maintaining Autophagic Balance: A Role for Brakes (Salvatore J Cherra, III and Charleen T Chu)Autophagy and Neurological Diseases:Autophagy and Its Cross-Talk with Cell Death in Neural Development (Sabrina Di Bartolomeo and Francesco Cecconi)Autophagy in the Retina: Development, Physiology and Pathology (Patricia Boya)Genetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Conditions (Masaaki Komatsu, Masato Koike, Yoshinobu Ichimura and Yasuo Uchiyama)Autophagy in Amyotrophic Lateral Sclerosis (Jozsef Gal and Haining Zhu)Autophagy Failure in Alzheimer's Disease and Lysosomal Storage Disorders: A Common Pathway to Neurodegeneration? (Devin M Wolfe and Ralph Nixon)Autophagy in Huntington's and Parkinson's Diseases: Pathogenic Mechanism and Therapeutic Potentials (Junghyun Lim, Lauren G Friedman, Nicole C McKnight and Zhenyu Yue)Metabolism, Autophagy and Neurodegeneration (W Haung Yu and Karen E Duff)The Potential of Autophagy Regulation in the Treatment of Neurodegenerative Diseases (Ashley R Winslow, Zeyn W Green-Thompson and David C Rubinsztein)Lysosome Storage Disorders on the Brain: The Autophagy-Lysosome Pathway Contributes to Disease Pathophysiology and May be Utilized for Therapeutic Benefit (John J Shacka)Specialized Autophagy: The New Frontier:Autophagy — Roles in Synaptic Structure and Function (Daniela Hernandez and David Sulzer)Neuronal Mitochondrial Transport and Turnover via Mitophagy (Zu-Hang Sheng and Charleen T Chu)Role of Autophagy in Neurite Degeneration In Vitro (Yi Yang, Xiaoxiang Zheng and Tatsuro Koike) Readership: Neurologists (clinical), molecular biologists (scientists), and college students. Keywords:Autophagy;Neurons;Neurodegeneration;Cell Death;Disease;Neuropathology;Neurological Disorders;Autophagosomes;Lysosomes;Degradation;Axons;Mitochondria;Chaperone Proteins;Alzheimer's Disease;Parkinson's Disease;Huntington's Disease;Protein AggregationKey Features:Collates the most recent research on autophagy regulation and critically examines the relevance of specific mechanisms to disease in light of unique aspects of neuronal cell biologyCovers newer knowledge of general autophagy processes, reviews the state of the art on specific aspects of autophagy regulation in neurons, and discusses the role of autophagy in neurodegenerative diseaseThe co-editors and contributing authors for each of the chapters are all experts, including some of the most influential figures in autophagy research and neurodegeneration


Sirtuins In Biology And Disease

Sirtuins in Biology and Disease PDF
Author: Tiago F. Outeiro
Publisher: Frontiers E-books
ISBN: 9782889191178
Size: 40.66 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages :
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Sirtuins In Biology And Disease

by Tiago F. Outeiro, Sirtuins In Biology And Disease Books available in PDF, EPUB, Mobi Format. Download Sirtuins In Biology And Disease books, Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.


Issues In Anatomy Physiology Metabolism Morphology And Human Biology 2011 Edition

Issues in Anatomy  Physiology  Metabolism  Morphology  and Human Biology  2011 Edition PDF
Author:
Publisher: ScholarlyEditions
ISBN: 1464964769
Size: 72.48 MB
Format: PDF
Category : Science
Languages : en
Pages : 1251
View: 944

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Issues In Anatomy Physiology Metabolism Morphology And Human Biology 2011 Edition

by , Issues In Anatomy Physiology Metabolism Morphology And Human Biology 2011 Edition Books available in PDF, EPUB, Mobi Format. Download Issues In Anatomy Physiology Metabolism Morphology And Human Biology 2011 Edition books, Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Anatomy, Physiology, Metabolism, Morphology, and Human Biology. The editors have built Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anatomy, Physiology, Metabolism, Morphology, and Human Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Anatomy, Physiology, Metabolism, Morphology, and Human Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.


Autophagy In Health And Disease

Autophagy in Health and Disease PDF
Author: Kursad Turksen
Publisher: Springer
ISBN: 3319981463
Size: 59.45 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 177
View: 797

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Autophagy In Health And Disease

by Kursad Turksen, Autophagy In Health And Disease Books available in PDF, EPUB, Mobi Format. Download Autophagy In Health And Disease books, This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.


Autophagy Infection And The Immune Response

Autophagy  Infection  and the Immune Response PDF
Author: William T. Jackson
Publisher: John Wiley & Sons
ISBN: 1118677641
Size: 21.12 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 352
View: 7405

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Autophagy Infection And The Immune Response

by William T. Jackson, Autophagy Infection And The Immune Response Books available in PDF, EPUB, Mobi Format. Download Autophagy Infection And The Immune Response books, The relationship between infection and immunity and autophagy, a pathway of cellular homeostasis and stress response, has been a rapidly growing field of study over the last decade. While some cellular processes are pro- or anti-infection, autophagy has been proven to be both: a part of the innate immune response against some microbes, and a cellular pathway subverted by some pathogens to promote their own replication. Autophagy, Infection, and the Immune Response provides a unified overview of the roles of cellular autophagy during microbial infection. Introductory chapters ground the reader by delineating the autophagic pathway from a cellular perspective, and by listing assays available for measuring autophagy. Subsequent chapters address virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma. Designed as a resource for those interested in initiating studies on the relationship between autophagy and infection or immunity, Autophagy, Infection, and the Immune Response combines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.


International Review Of Cell And Molecular Biology

International Review of Cell and Molecular Biology PDF
Author: Kwang W. Jeon
Publisher: Academic Press
ISBN: 012394306X
Size: 70.86 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 335
View: 3162

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International Review Of Cell And Molecular Biology

by Kwang W. Jeon, International Review Of Cell And Molecular Biology Books available in PDF, EPUB, Mobi Format. Download International Review Of Cell And Molecular Biology books, International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2010: 4.954. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists