Chirality In Industry Ii

Chirality in Industry II PDF
Author: A. N. Collins
Publisher: John Wiley & Sons
ISBN: 9780471982845
Size: 39.28 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 418
View: 3914

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Chirality In Industry Ii

by A. N. Collins, Chirality In Industry Ii Books available in PDF, EPUB, Mobi Format. Download Chirality In Industry Ii books, This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II All new case histories Unique industrial perspective on chiral technology Emphasis on scale-up and process development Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.


Chirality In Industry The Commercial Manufacture And Applications Of Optically Active Compounds And Chirality In Industry Ii Developments In The Commercial Manufacture And Applications Of Optically Active Compounds Two Volume Set

Chirality in Industry  The Commercial Manufacture and Applications of Optically Active Compounds and Chirality in Industry II  Developments in the Commercial Manufacture and Applications of Optically Active Compounds  Two Volume Set PDF
Author: A. N. Collins
Publisher: Wiley
ISBN: 9780471984177
Size: 46.90 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 844
View: 4097

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Chirality In Industry The Commercial Manufacture And Applications Of Optically Active Compounds And Chirality In Industry Ii Developments In The Commercial Manufacture And Applications Of Optically Active Compounds Two Volume Set

by A. N. Collins, Chirality In Industry The Commercial Manufacture And Applications Of Optically Active Compounds And Chirality In Industry Ii Developments In The Commercial Manufacture And Applications Of Optically Active Compounds Two Volume Set Books available in PDF, EPUB, Mobi Format. Download Chirality In Industry The Commercial Manufacture And Applications Of Optically Active Compounds And Chirality In Industry Ii Developments In The Commercial Manufacture And Applications Of Optically Active Compounds Two Volume Set books, The manufacture and applications of chiral compounds continue to develop. Building on the case studies format of the first volume, this text concentrates on different syntheses and the developments in the field. It presents a comprehensive picture of the technologies required for the production of optically active molecules on the multi-Kg to high tonnage scales, as well as illustrating the breadth of application of the products of these technologies. This volume is divided into sections on physical methods and classical resolutions, biological methods and the chiral pool, and asymmetric synthesis. These are preceded by a chapter dealing with regulatory issues for chiral drugs and two chapters on chiral drug development which illustrates how widely the industrial practitioner must cast the net in pursuit of practical production methods.


Chirality In Industry Ii

Chirality in Industry II PDF
Author: A. N. Collins
Publisher: Wiley
ISBN: 9780471966807
Size: 76.79 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 418
View: 1693

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Chirality In Industry Ii

by A. N. Collins, Chirality In Industry Ii Books available in PDF, EPUB, Mobi Format. Download Chirality In Industry Ii books, This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II * All new case histories * Unique industrial perspective on chiral technology * Emphasis on scale-up and process development * Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.


Chirality In Industry Ii

Chirality in Industry II PDF
Author: A. N. Collins
Publisher: Wiley
ISBN: 9780471966807
Size: 70.89 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 418
View: 6789

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Chirality In Industry Ii

by A. N. Collins, Chirality In Industry Ii Books available in PDF, EPUB, Mobi Format. Download Chirality In Industry Ii books, This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II * All new case histories * Unique industrial perspective on chiral technology * Emphasis on scale-up and process development * Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.


Chirality In Drug Research

Chirality in Drug Research PDF
Author: Eric Francotte
Publisher: John Wiley & Sons
ISBN: 3527608710
Size: 59.69 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 370
View: 2200

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Chirality In Drug Research

by Eric Francotte, Chirality In Drug Research Books available in PDF, EPUB, Mobi Format. Download Chirality In Drug Research books, Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.


Chiral Drugs

Chiral Drugs PDF
Author: Cynthia A Challener
Publisher: Routledge
ISBN: 1351808044
Size: 22.77 MB
Format: PDF, Docs
Category : Social Science
Languages : en
Pages : 662
View: 3307

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Chiral Drugs

by Cynthia A Challener, Chiral Drugs Books available in PDF, EPUB, Mobi Format. Download Chiral Drugs books, This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.


Handbook Of Chiral Chemicals

Handbook Of Chiral Chemicals PDF
Author: David John Ager
Publisher: CRC Press
ISBN: 9780824746292
Size: 78.68 MB
Format: PDF
Category : Science
Languages : en
Pages : 384
View: 7277

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Handbook Of Chiral Chemicals

by David John Ager, Handbook Of Chiral Chemicals Books available in PDF, EPUB, Mobi Format. Download Handbook Of Chiral Chemicals books, Describes the problems associated with large, commercial-scale syntheses of chiral molecules and the relatively small number of reactions that can be used to achieve these syntheses. The book discusses commercially viable and still-developing methods of compound manufacture, and reviews the best-selling chiral compounds as of 1996.


Handbook Of Chiral Chemicals Second Edition

Handbook of Chiral Chemicals  Second Edition PDF
Author: David Ager
Publisher: CRC Press
ISBN: 9781420027303
Size: 77.47 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 664
View: 2205

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Handbook Of Chiral Chemicals Second Edition

by David Ager, Handbook Of Chiral Chemicals Second Edition Books available in PDF, EPUB, Mobi Format. Download Handbook Of Chiral Chemicals Second Edition books, As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook first elaborates upon starting materials obtained from a 'chiral pool', which can be derived from natural products. Then it explains methods and reactions that can introduce or influence stereogenic centers, particularly asymmetric hydrogenations, oxidations, pericyclic reactions, and enzymatic methods.While hydrogenations have been the most widely employed approach for the large-scale synthesis of several commercial compounds, the search for the ideal catalyst has consistently led researchers to enzymes present in biological systems. Several chapters concentrate on understanding how to manipulate enzymes for catalyzing new reactions for taking new substrates. Other significant topics include chiral auxiliaries, chromatographic techniques, enantiomers-specific reactions, and resolution. This second edition updates all its chapters, illustrating the speed of development in this field, and features new chapters that highlight successful approaches in an industrial setting. "The Handbook of Chiral Chemicals, Second Edition" is a guide to advances in the field that result in more efficient and cost-effective synthesis of chiral chemicals.


Chirotechnology

Chirotechnology PDF
Author: Roger A. Sheldon
Publisher: CRC Press
ISBN: 9780824791438
Size: 37.56 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 423
View: 3994

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Chirotechnology

by Roger A. Sheldon, Chirotechnology Books available in PDF, EPUB, Mobi Format. Download Chirotechnology books, This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.


Chiral Intermediates

Chiral Intermediates PDF
Author: Cynthia A. Challener
Publisher: John Wiley & Sons Incorporated
ISBN:
Size: 26.61 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 804
View: 4288

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Chiral Intermediates

by Cynthia A. Challener, Chiral Intermediates Books available in PDF, EPUB, Mobi Format. Download Chiral Intermediates books, In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Intermediates presents the chemical professional with a comprehensive listing of over 4700 available chiral chemicals including specific data of interest for each entry in the listing. Its companion volume, Chiral Drugs presents the same detailed information for over 2000 chiral drugs. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part I contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part II presents entries for 4700 commercially available chiral compounds. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.