Cord Blood

Cord Blood PDF
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309095867
Size: 54.17 MB
Format: PDF
Category : Medical
Languages : en
Pages : 334
View: 6070

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Cord Blood

by Institute of Medicine, Cord Blood Books available in PDF, EPUB, Mobi Format. Download Cord Blood books, With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.


Cord Blood Stem Cells Medicine

Cord Blood Stem Cells Medicine PDF
Author: Catherine Stavropoulos-Giokas
Publisher: Elsevier
ISBN: 0124078362
Size: 19.92 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 398
View: 6658

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Cord Blood Stem Cells Medicine

by Catherine Stavropoulos-Giokas, Cord Blood Stem Cells Medicine Books available in PDF, EPUB, Mobi Format. Download Cord Blood Stem Cells Medicine books, Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. Comprehensive coverage of the medical application of cord blood stem cells Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine Covers new applications of cord blood stem cells, particularly transplantation and HIV Introduces new technologies for cord blood stem cells and regenerative medicine


Frontiers Of Cord Blood Science

Frontiers of Cord Blood Science PDF
Author: Niranjan Bhattacharya
Publisher: Springer Science & Business Media
ISBN: 9781848001671
Size: 72.57 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 400
View: 2667

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Frontiers Of Cord Blood Science

by Niranjan Bhattacharya, Frontiers Of Cord Blood Science Books available in PDF, EPUB, Mobi Format. Download Frontiers Of Cord Blood Science books, Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.


Umbilical Cord Blood

Umbilical Cord Blood PDF
Author: Suzanne Kadereit
Publisher: World Scientific
ISBN: 9812833293
Size: 22.45 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 347
View: 3722

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Umbilical Cord Blood

by Suzanne Kadereit, Umbilical Cord Blood Books available in PDF, EPUB, Mobi Format. Download Umbilical Cord Blood books, Umbilical cord blood, previously discarded after birth, has emerged over recent years as an alternative source of hematopoietic stem cells for hematological reconstitution, mainly for leukemia patients, as well as for some hematological deficiencies and bone marrow failures. In recent years, it has become increasingly clear that cord blood, as well as the surrounding tissue of the umbilical cord, contain additional stem cells which have been shown to be of great potential for regenerative medicine. Importantly, cord blood is abundant, it can be banked and shipped with ease, and thus has an indisputable potential for future medicines and regenerative therapies. Driven by a massive interest for regenerative medicine and alternative yet ethically acceptable stem cell sources, the scientific literature on umbilical cord and cord blood stem cells has increased tremendously. This book provides a consolidated, up-to-date overview of basic research on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently described stem and precursor cells of not yet fully elucidated potential. It also takes an in-depth look at basic and translational research efforts with stem cells from the umbilical cord in academic institutions and biotech companies. Suitable for use as a primer and reference book by medical fellows and researchers entering the research fields of stem cell biology and regenerative medicine, it can also be used by students (undergraduate and graduate) as a starting point for read-up on the literature on stem cells and their potential and applications, or as a teaching tool in graduate schools for biologists, particularly for students wanting to enter the emerging field of stem cell biology.


Cord Blood Transplantations

Cord Blood Transplantations PDF
Author: Mitchell Horwitz
Publisher: Springer
ISBN: 3319536281
Size: 40.32 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 296
View: 3953

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Cord Blood Transplantations

by Mitchell Horwitz, Cord Blood Transplantations Books available in PDF, EPUB, Mobi Format. Download Cord Blood Transplantations books, In this book, experts in the field express their well-reasoned opinions on a spectrum of important and complex issues in the area of cord blood transplantation. The aim is to provide practicing hematologists, including hematopoietic transplant physicians, with clinically relevant and immediately applicable information that will assist in the delivery of optimal care. The book opens by offering a historical perspective and examining current concepts and practices in cord blood banking. Sections are then devoted to strategies for cord blood graft selection and to areas of consensus and controversy in cord blood transplantation for neoplastic diseases - and nonmalignant - in children and adults. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. This book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients and will offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.


Umbilical Cord Blood Banking And Transplantation

Umbilical Cord Blood Banking and Transplantation PDF
Author: Karen Ballen
Publisher: Springer
ISBN: 3319064444
Size: 72.48 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 286
View: 2468

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Umbilical Cord Blood Banking And Transplantation

by Karen Ballen, Umbilical Cord Blood Banking And Transplantation Books available in PDF, EPUB, Mobi Format. Download Umbilical Cord Blood Banking And Transplantation books, This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient. UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.


Stem Cells From Cord Blood In Utero Stem Cell Development And Transplantation Inclusive Gene Therapy

Stem Cells from Cord Blood  in Utero Stem Cell Development and Transplantation Inclusive Gene Therapy PDF
Author: W. Holzgreve
Publisher: Springer Science & Business Media
ISBN: 3662044692
Size: 72.29 MB
Format: PDF
Category : Medical
Languages : en
Pages : 229
View: 4353

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Stem Cells From Cord Blood In Utero Stem Cell Development And Transplantation Inclusive Gene Therapy

by W. Holzgreve, Stem Cells From Cord Blood In Utero Stem Cell Development And Transplantation Inclusive Gene Therapy Books available in PDF, EPUB, Mobi Format. Download Stem Cells From Cord Blood In Utero Stem Cell Development And Transplantation Inclusive Gene Therapy books, The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex perimental and only investigated in medical centers with the appropri ate background. It is, however, not only justified, but helpful to com bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".


Blood Banking And Transfusion Medicine

Blood Banking and Transfusion Medicine PDF
Author: Christopher D. Hillyer
Publisher: Elsevier Health Sciences
ISBN: 0443069816
Size: 70.11 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 887
View: 2033

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Blood Banking And Transfusion Medicine

by Christopher D. Hillyer, Blood Banking And Transfusion Medicine Books available in PDF, EPUB, Mobi Format. Download Blood Banking And Transfusion Medicine books, Ever since the discovery of blood types early in the last century, transfusion medicine has evolved at a breakneck pace. This second edition of Blood Banking and Transfusion Medicine is exactly what you need to keep up. It combines scientific foundations with today's most practical approaches to the specialty. From blood collection and storage to testing and transfusing blood components, and finally cellular engineering, you'll find coverage here that's second to none. New advances in molecular genetics and the scientific mechanisms underlying the field are also covered, with an emphasis on the clinical implications for treatment. Whether you're new to the field or an old pro, this book belongs in your reference library. Integrates scientific foundations with clinical relevance to more clearly explain the science and its application to clinical practice. Highlights advances in the use of blood products and new methods of disease treatment while providing the most up-to-date information on these fast-moving topics Discusses current clinical controversies, providing an arena for the discussion of sensitive topics. Covers the constantly changing approaches to stem cell transplantation and brings you the latest information on this controversial topic.


Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues

Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues PDF
Author: Dong-Hyuk Park
Publisher:
ISBN:
Size: 31.64 MB
Format: PDF
Category : Technology
Languages : en
Pages :
View: 5869

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Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues

by Dong-Hyuk Park, Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues Books available in PDF, EPUB, Mobi Format. Download Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues books, Human Umbilical Cord Blood Stem Cells Rescue Ischemic Tissues.


Cord Blood Stem Cell Processing Banking And Thawing

Cord Blood Stem Cell Processing  Banking and Thawing PDF
Author: Robert Y.K. Chow
Publisher:
ISBN:
Size: 65.99 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages :
View: 5955

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Cord Blood Stem Cell Processing Banking And Thawing

by Robert Y.K. Chow, Cord Blood Stem Cell Processing Banking And Thawing Books available in PDF, EPUB, Mobi Format. Download Cord Blood Stem Cell Processing Banking And Thawing books, Unrelated donor cord blood (CB) is one of the three sources of hematopoietic stem cell transplantation (HSCT) that are capable of curing ~80-160 standard hematologic and certain non-hematologic indications. Despite its many advantages, the principal drawback for CB in HSCT is its limited cell dose. Our group has focused on developing minimally manipulated technologies and strategies to maximize stem, progenitor, and nucleated cell doses to overcome this limitation. The term "MaxCell" is used in this chapter to denote two proprietary CB volume reduction processing technologies that yield virtually 100% recovery of all cell lineages in the manufactured CB products, including what the authors designate as "second generation" (2nd Gen) or plasma depletion/reduction (PDR) and "third generation" (3rd Gen) MaxCB or MaxCord CB processing technologies. In our proposed nomenclature system, the traditional red cell reduction (RCR) processing techniques are designated as "first generation" methods. The properties of various popular 1st Gen techniques are compared to the MaxCell CB processing technologies. Parallel processing with the traditional hetastarch (HES) RCR technique and the patented MaxCell CB processing technology were used to compare recovery of the various stem, progenitor, nucleated, and red cell lineages. MaxCell processing technology achieved virtually 100% recovery of all stem, progenitor, and nucleated cells tested after processing, with high cell viability upon thawing. The higher cell recovery produced MaxCell inventory with higher average stem, progenitor and nucleated cell doses, allowing patients to receive CB products with higher cell doses. Clinical outcome of HSCT using MaxCell CB products was compared to the outcome of HSCT with RCR CB products published in the literature from transplant data registries or CB banks. To allow for more rigorous comparisons, two matched-pair analysis (MP) were performed using a logistic regression model to find pairs of pediatric patients with hematologic malignancies and thalassemia transplanted with RCR CB or MaxCell CB, and patients receiving MaxCell CB showed superior engraftment, survival, and transplant-related mortality, confirming pre-match observations.