How To Overcome The Antibiotic Crisis

How to Overcome the Antibiotic Crisis PDF
Author: Marc Stadler
Publisher: Springer
ISBN: 3319492845
Size: 51.87 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 496
View: 3151

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How To Overcome The Antibiotic Crisis

by Marc Stadler, How To Overcome The Antibiotic Crisis Books available in PDF, EPUB, Mobi Format. Download How To Overcome The Antibiotic Crisis books, This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.


Recent Advances In Pediatrics 21 Hot Topics

Recent Advances in Pediatrics   21   Hot Topics PDF
Author: Suraj Gupte
Publisher: JP Medical Ltd
ISBN: 9350257742
Size: 53.39 MB
Format: PDF
Category : Medical
Languages : en
Pages : 505
View: 3793

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Recent Advances In Pediatrics 21 Hot Topics

by Suraj Gupte, Recent Advances In Pediatrics 21 Hot Topics Books available in PDF, EPUB, Mobi Format. Download Recent Advances In Pediatrics 21 Hot Topics books, Volume 21 of Recent Advances in Pediatrics is a compilation of reviews bringing trainees and physicians fully up to date with key developments in the field. Topics in this new volume include advances in neonatology, nutrition, gastroenterology and hepatology, psychiatry, endocrinology and critical care. Separate chapters are dedicated to vaccines and pharmacotherapy. Presented in an easy to follow format, Volume 21 follows a multidisciplinary approach. Each chapter finishes with a summary of key learning points and extensive references for further reading. Clinical photographs, illustrations and tables enhance learning. Key points New, updated volume presenting latest developments in paediatrics Multidisciplinary approach, easy to follow format Extensive references and key learning points summarised in each chapter Hot Topics Volume 20 published in 2011


Preclinical Evaluation Of Antimicrobial Nanodrugs

Preclinical Evaluation of Antimicrobial Nanodrugs PDF
Author: Juan Bueno
Publisher: Springer Nature
ISBN: 3030438554
Size: 23.67 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 117
View: 4709

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Preclinical Evaluation Of Antimicrobial Nanodrugs

by Juan Bueno, Preclinical Evaluation Of Antimicrobial Nanodrugs Books available in PDF, EPUB, Mobi Format. Download Preclinical Evaluation Of Antimicrobial Nanodrugs books, Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.


New And Future Developments In Microbial Biotechnology And Bioengineering

New and Future Developments in Microbial Biotechnology and Bioengineering PDF
Author: Ali Asghar Rastegari
Publisher: Elsevier
ISBN: 0128205296
Size: 19.53 MB
Format: PDF, ePub, Mobi
Category : Technology & Engineering
Languages : en
Pages : 312
View: 2972

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New And Future Developments In Microbial Biotechnology And Bioengineering

by Ali Asghar Rastegari, New And Future Developments In Microbial Biotechnology And Bioengineering Books available in PDF, EPUB, Mobi Format. Download New And Future Developments In Microbial Biotechnology And Bioengineering books, New and Future Developments in Microbial Biotechnology and Bioengineering: Trends of Microbial Biotechnology for Sustainable Agriculture and Biomedicine Systems: Perspectives for Human Health discusses how microbial biotechnology helps us understand new strategies to reduce pathogens and drug resistance through microbial biotechnology. The most commonly used probiotic bacteria are Lactobacillus and Bifidobacterium. Therefore, the probiotic strains exhibit powerful anti-inflammatory, antiallergic and other important properties. This new book provides an indispensable reference source for engineers/bioengineers, biochemists, biotechnologists, microbiologists, pharmacologists, and researchers who want to know about the unique properties of this microbe and explore its sustainable biomedicine future applications. Introduces the principles of microbial biotechnology and its application for sustainable biomedicine system Explores various microbes and their beneficial application for biofortification of crops for micronutrients Explains the potentials and significance of probiotics, prebiotics and synbiotics in health and disease Includes current applications of beneficial microbes as Functional Food Products of Pharmaceutical Importance


Hurdles For Phage Therapy Pt To Become A Reality

Hurdles for Phage Therapy  PT  to Become a Reality PDF
Author: Harald Brüssow
Publisher: MDPI
ISBN: 3039213911
Size: 60.87 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 484
View: 4839

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Hurdles For Phage Therapy Pt To Become A Reality

by Harald Brüssow, Hurdles For Phage Therapy Pt To Become A Reality Books available in PDF, EPUB, Mobi Format. Download Hurdles For Phage Therapy Pt To Become A Reality books, Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.


Antibiotic Resistance

Antibiotic Resistance PDF
Author: Karl S. Drlica
Publisher: FT Press
ISBN: 9780132117326
Size: 55.37 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 288
View: 3284

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Antibiotic Resistance

by Karl S. Drlica, Antibiotic Resistance Books available in PDF, EPUB, Mobi Format. Download Antibiotic Resistance books, Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.


Antitrust

Antitrust PDF
Author:
Publisher: Law Journal Press
ISBN: 9781588520197
Size: 60.47 MB
Format: PDF, ePub
Category :
Languages : en
Pages :
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Antitrust

by , Antitrust Books available in PDF, EPUB, Mobi Format. Download Antitrust books,


The Plague Pit

The Plague Pit PDF
Author: Marc Alexander
Publisher: Lulu.com
ISBN: 1909473197
Size: 12.35 MB
Format: PDF, Mobi
Category :
Languages : en
Pages :
View: 6997

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The Plague Pit

by Marc Alexander, The Plague Pit Books available in PDF, EPUB, Mobi Format. Download The Plague Pit books,


Applied Pharmacometrics

Applied Pharmacometrics PDF
Author: Stephan Schmidt
Publisher: Springer
ISBN: 1493913042
Size: 35.14 MB
Format: PDF
Category : Medical
Languages : en
Pages : 565
View: 1461

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Applied Pharmacometrics

by Stephan Schmidt, Applied Pharmacometrics Books available in PDF, EPUB, Mobi Format. Download Applied Pharmacometrics books, This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer’s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.


Investigation Of New Pantothenate Derivatives To Combat The Antimicrobial Crisis

Investigation of New Pantothenate Derivatives to Combat the Antimicrobial Crisis PDF
Author: Jinming Guan
Publisher:
ISBN:
Size: 13.50 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages :
View: 4633

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Investigation Of New Pantothenate Derivatives To Combat The Antimicrobial Crisis

by Jinming Guan, Investigation Of New Pantothenate Derivatives To Combat The Antimicrobial Crisis Books available in PDF, EPUB, Mobi Format. Download Investigation Of New Pantothenate Derivatives To Combat The Antimicrobial Crisis books, "Antimicrobial resistance has been an increasing public health threat in the world, due to the rapid evolution and gene transfers by microbes. Various efforts have been taken to combat antimicrobial resistance, spanning from a drive to identify unexploited antimicrobial targets to a renewed push for novel antimicrobial agents. Coenzyme A (CoA) is an essential cofactor for all living organisms. It is generally biosynthesized in five universal enzymatic steps. Although this five-step pathway is conserved in various organisms, the involved enzymes differ significantly between organisms. Therefore, focusing on the CoA biosynthetic pathway, this thesis exploits three strategies that have potential to overcome antimicrobial resistance. The first strategy used is to revisit an old, unexploited class of antimicrobials: pantothenamides, which are secondary or tertiary amides of pantothenic acid. This class of compounds exerts antimicrobial activity via a new mode of action, interfering the CoA-related pathway. Despite their interesting antimicrobial activity, their clinical use is however hindered due to their instability in human serum. To address the instability issue of pantothenamides, in chapter 2, a cross-metathesis approach to install larger groups at the geminal dimethyl position of pantothenamides was successfully developed, and was demonstrated to be an effective way to impart stability to pantothenamides in human serum. In chapter 3 and 4, a pantothenamide analogue which has the labile amide bond replaced with a stable triazole ring, was used to design a series of new pantothenamide derivatives. Overall, three new nanomolar antiplasmodial heteroaromatic pantothenamide analogues were discovered. The results also revealed a new way by which triazoles mimic amide bonds.The second strategy seeks novel antimicrobial targets. Pantothenate kinase (PanK), which catalyzes the phosphorylation of pantothenate to 4’-phosphopantothenate, is the first enzyme in the CoA biosynthetic pathway. It can be classified into three types (type I, II and III). Several inhibitors and alternative substrates have been reported for type I and II, whereas only weak inhibitors have been reported for type III. To design better inhibitors and substrates for not only type I and II PanK but also type III PanK, a small series of pantothenate analogues were synthesized in chapter 5. They were exploited as probes to compare the ligand preference of the three types of bacterial PanK. Overall, several new inhibitors and substrates were identified for each type of bacterial PanK. The third strategy involves reactivating old antibiotics. Effectiveness of aminoglycosides can be reduced towards bacteria after being acetylated by an aminoglycoside acetyltransferase. As an aminoglycoside potentiator, P-1b can effectively restore the effectiveness of aminoglycosides towards resistant bacteria. P-1b was suggested to exert its potentiating effect after being transformed by the CoA biosynthetic pathway to a CoA derivative which inhibits the acetyltransferase in resistant bacteria. To better understand the mechanism of action of P-1b, a series of in cellulo studies was performed and reported in chapter 6. The results revealed a new acetyltransferase inhibitor, and suggested that P-1b may be transformed into more than one acetyltransferase inhibitors in bacteria"--