Intracellular Protein Catabolism

Intracellular Protein Catabolism PDF
Author: Koichi Suzuki
Publisher: Springer Science & Business Media
ISBN: 1461303354
Size: 48.17 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 320
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Intracellular Protein Catabolism

by Koichi Suzuki, Intracellular Protein Catabolism Books available in PDF, EPUB, Mobi Format. Download Intracellular Protein Catabolism books, The Tenth International Conference on Intracellular Protein Catabolism was held in Tokyo Japan, October 30-November 3, 1994. under the auspices of the International Committee on Proteolysis (lCOP). ICOP meetings have been held biennially in the USA, Europe, and Japan in turn. The previous three ICOP meetings (7th to 9th) were held in Shimoda, Japan, in 1988. in WildbadKreuth, Germany, in 1990, and in Williamsburg. Virginia, in 1992. Previous meetings were held in resort areas, this was the first meeting held in a large city. Attendance has grown every year so that nearly 400 participants from 19 different countries attended the Tokyo meeting. At the meeting, novel and updated results on the structure-function. physiology, biology, and pathology of proteases and inhibitors were discussed, together with cellular aspects of proteolysis and protein turnover. Thirty-nine invited papers and eight selected posters were presented orally and 171 poster presentations were discussed. This book documents almost all of the lectures and some selected posters. Since the world of proteolysis and protein turnover is expanding very rapidly. far beyond our expectations, it is impossible to cover all the new aspects of this field. However, this book will give an idea of the current status, trends. and directions of the field, and information necessary to understand what is and will be important in this field. Further. the editors hope that the novel ideas, approaches. methodologies, and important findings described in this book will stimulate further study on proteolysis and protein turnover.


Intracellular Protein Catabolism Ii

Intracellular Protein Catabolism II PDF
Author: Vito Turk
Publisher: Springer Science & Business Media
ISBN: 1461588138
Size: 40.11 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 368
View: 1969

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Intracellular Protein Catabolism Ii

by Vito Turk, Intracellular Protein Catabolism Ii Books available in PDF, EPUB, Mobi Format. Download Intracellular Protein Catabolism Ii books, This book contains most of the papers presented . at the Second International Symposium on Intracellular Protein OItaboiism, which was held on May 26-30,1975 in Ljubljana, Yugoslavia. The papers presented in this book cover a wide variety of areas related to protein turnover and responsible enzymes. The symposium attracted about one hundred parti cipants, and the cordial atmosphere, the frank discussions and the exchange of ideas were a stimulant for all those attending_ During the last decade, investigations in the wide field of intracellular protein catabolism have been rapidly taken up in many laboratories, because the mechanisms and regulation of degradative processes are rather less studied compared to synthetic processes. In view of this increased interest, Prof. H. Hanson and his coworkers organized the First Interna tional Symposium and the papers presented there were published in the book Intracellular Protein Catabolism, edited by H. Hanson and P. Bohley. In the preface of this book they concluded: "We hope, however, the symposium as well as the book will be the beginning of a series of symposia and their publication concerning intracellular protein catabolism. " We would like to express our thanks for financial support provided by the Research Council of Slovenia. Special thanks are due to the organizing committee of the symposium, and to Dr. I. Kregar and particularly Dr. J. Babnik for their efforts in preparing manuscripts for the publishers.


Constant Protein Catabolism Of Walker Carcinoma 256 And Human Skin Epithelium In Tissue Culture

Constant Protein Catabolism of Walker Carcinoma 256 and Human Skin Epithelium in Tissue Culture PDF
Author: Harry C. Jordan
Publisher:
ISBN:
Size: 51.69 MB
Format: PDF, Docs
Category : Proteins
Languages : en
Pages : 97
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Constant Protein Catabolism Of Walker Carcinoma 256 And Human Skin Epithelium In Tissue Culture

by Harry C. Jordan, Constant Protein Catabolism Of Walker Carcinoma 256 And Human Skin Epithelium In Tissue Culture Books available in PDF, EPUB, Mobi Format. Download Constant Protein Catabolism Of Walker Carcinoma 256 And Human Skin Epithelium In Tissue Culture books,


Intracellular Protein Degradation

Intracellular Protein Degradation PDF
Author: A.J. Rivett
Publisher: Elsevier Science
ISBN: 9780762303878
Size: 58.41 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 301
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Intracellular Protein Degradation

by A.J. Rivett, Intracellular Protein Degradation Books available in PDF, EPUB, Mobi Format. Download Intracellular Protein Degradation books, This volume brings together a set of reviews that provide a summary of our current knowledge of the proteolytic machinery and of the pathways of protein breakdown of prokaryotic and eukaryotic cells. Intracellular protein degradation is much more than just a mechanism for the removal of incorrectly folded or damaged proteins. Since many short-lived proteins have important regulatory functions, proteolysis makes a significant contribution to many cellular processes including cell cycle regulation and transciptional control. In addition, limited proteolytic cleavage can provide a rapid and efficient mechanism of enzyme activation or inactivation in eukaryotic cells. In the first chapter, Maurizi provides an introduction to intracellular protein degradation, describes the structure and functions of bacterial ATP-dependent proteases, and explores the relationship between chaperone functions and protein degradation. Many of the principles also apply to eukaryotic cells, although the proteases involved are often not the same. Interestingly, homologues of one of the bacterial proteases, Ion protease, have been found in mitochondria in yeast and mammals, and homologues of proteasomes, which are found in all eukaryotic cells (see below), have been discovered in some eubacteria. Studies of proteolysis in yeast have contributed greatly to the elucidation of both lysosomal (vacuolar) and nonlysosomal proteolytic pathways in eukaryotic cells. Thumm and Wolf (chapter 2) describe studies that have elucidated the functions of proteasomes in nonlysosomal proteolysis and the contributions of lysosomal proteases to intracellular protein breakdown. Proteins can be selected for degradation by a variety of differen mechanisms. The ubiquitin system is one complex and highly regulated mechanism by which eukaryotic proteins are targetted for degradation by proteosomes. In chapter 3, Wilkinson reviews the components and functions of the ubiquitin system and considers some of the known substrates for this pathway which include cell cycle and transcriptional regulators. The structure and functions of proteosomes and their regulatory components are described in the two subsequent chapters by Tanaka and Tanahashi and by Dubiel and Rechsteiner. Proteasomes were the first known example of threonine proteases. They are multisubunit complexes that, in addition to being responsible for the turnover of most short-lived nuclear and cytoplasmic protein, are also involved in antigen processing for presentation by the MHC class I pathway. Recent studies reviewed by McCracken and colleagues (chapter 6) lead to the exciting conclusion that some ER-associated proteins are degraded by cytosolic proteasomes. Lysosomes are responsible for the degradation of long-lived proteins and for the enhanced protein degradation observed under starvation conditions. In chapter 7 Knecht and colleagues review the lysosomal proteases and describe studies of the roles of lysosomes and the mechanisms for protein uptake into lysosomes. Methods of measuring the relative contribution of different proteolytic systems (e.g., ubiquitin-proteasome pathway, calcium-dependent proteases, lysosomes) to muscle protein degradation, and the conclusions from such studies, are reviewed by Attai and Taillinder in the following chapter. Finally, proteases play an important role in signaling apoptosis by catalyzing the limited cleavage of enzymes. Mason and Beyette review the role of the major players, caspases, which are both activated by and catalyze limite proteolysis, and also consider the involvement of other protoelytic enzymes in this pathway leading cell death.


Biological Functions Of Proteinases

Biological Functions of Proteinases PDF
Author: H. Holzer
Publisher: Springer Science & Business Media
ISBN: 364281395X
Size: 74.64 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 284
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Biological Functions Of Proteinases

by H. Holzer, Biological Functions Of Proteinases Books available in PDF, EPUB, Mobi Format. Download Biological Functions Of Proteinases books,


Proteases Ii

Proteases II PDF
Author: Walter H. Hörl
Publisher: Springer Science & Business Media
ISBN: 1461310571
Size: 55.94 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 572
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Proteases Ii

by Walter H. Hörl, Proteases Ii Books available in PDF, EPUB, Mobi Format. Download Proteases Ii books,