High Throughput Screening

High Throughput Screening PDF
Author: William P. Janzen
Publisher: Springer Science & Business Media
ISBN: 1592591809
Size: 31.48 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 265
View: 6536

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High Throughput Screening

by William P. Janzen, High Throughput Screening Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening books, Since its first use in antibiotic research in the 1940s, High Throughput Screening (HTS) has evolved into a major enabling tool and methodology in the discovery of pharmaceutical, chemical, and agricultural compounds. In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wished had been available when they started in HTS, these seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge. By presenting accounts not only of the basic principles underlying HTS technology, but also real-use cases, High Throughput Screening constitutes a highly practical introduction to HTS, even as it also provides sufficient detail to work more productively in today's lead generation laboratories.


High Throughput Screening In Downstream Processing Of Biotechnological Products

High Throughput Screening in Downstream Processing of Biotechnological Products PDF
Author: Matthias Wiendahl
Publisher: Cuvillier Verlag
ISBN: 3867276358
Size: 11.30 MB
Format: PDF, ePub, Docs
Category :
Languages : en
Pages : 138
View: 6947

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High Throughput Screening In Downstream Processing Of Biotechnological Products

by Matthias Wiendahl, High Throughput Screening In Downstream Processing Of Biotechnological Products Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening In Downstream Processing Of Biotechnological Products books,


High Throughput Screening Methods

High Throughput Screening Methods PDF
Author: Joshua A Bittker
Publisher: Royal Society of Chemistry
ISBN: 1782626778
Size: 48.55 MB
Format: PDF
Category : Medical
Languages : en
Pages : 396
View: 6878

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High Throughput Screening Methods

by Joshua A Bittker, High Throughput Screening Methods Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening Methods books, High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.


High Throughput Screening Methods Techniques And Applications

High Throughput Screening  Methods  Techniques and Applications PDF
Author: Geoff Holdgate
Publisher:
ISBN: 9781536172485
Size: 24.68 MB
Format: PDF, ePub
Category :
Languages : en
Pages : 490
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High Throughput Screening Methods Techniques And Applications

by Geoff Holdgate, High Throughput Screening Methods Techniques And Applications Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening Methods Techniques And Applications books, High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In this book leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. The book provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, this book provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both todays and the hit identification laboratories of the future.


Optimal High Throughput Screening

Optimal High Throughput Screening PDF
Author: Xiaohua Douglas Zhang
Publisher: Cambridge University Press
ISBN: 1139498371
Size: 21.26 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages :
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Optimal High Throughput Screening

by Xiaohua Douglas Zhang, Optimal High Throughput Screening Books available in PDF, EPUB, Mobi Format. Download Optimal High Throughput Screening books, This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.


High Throughput Screening In Chemical Catalysis

High Throughput Screening in Chemical Catalysis PDF
Author: Alfred Hagemeyer
Publisher: John Wiley & Sons
ISBN: 3527604308
Size: 39.22 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 339
View: 4481

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High Throughput Screening In Chemical Catalysis

by Alfred Hagemeyer, High Throughput Screening In Chemical Catalysis Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening In Chemical Catalysis books, In this first book to present every important aspect of this fascinating and developing field, the three editors A. Hagemeyer, P. Strasser and A. F. Volpe Jr. from Symyx Technologies have chosen a perfect mixture of distinguished, international authors from both academia and industry. Each chapter is devoted to a major topic - high-throughput experimentation methodologies, integrated combinatorial synthesis and screening workflow, and applications to chemical catalysts with an emphasis on heterogeneous catalysis, olefin polymerization and electrocatalysis for fuel cells. An indispensable source for everyone working in the field.


High Throughput Screening For Food Safety Assessment

High Throughput Screening for Food Safety Assessment PDF
Author: Arun K. Bhunia
Publisher: Elsevier
ISBN: 0857098071
Size: 52.39 MB
Format: PDF, ePub, Docs
Category : Technology & Engineering
Languages : en
Pages : 550
View: 5426

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High Throughput Screening For Food Safety Assessment

by Arun K. Bhunia, High Throughput Screening For Food Safety Assessment Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening For Food Safety Assessment books, Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables. Summarises the latest research on sensor technologies for online and high-throughput screening of food Covers high-throughput screening and the current and forecast state of rapid contaminant detection technologies Looks at the use of optical and electrochemical biosensors and hyperspectral imaging in food safety assessment and the application of these technologies in specific food products


High Throughput Screening

High Throughput Screening PDF
Author: John P. Devlin
Publisher: CRC Press
ISBN: 9780824700676
Size: 40.85 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 704
View: 384

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High Throughput Screening

by John P. Devlin, High Throughput Screening Books available in PDF, EPUB, Mobi Format. Download High Throughput Screening books, Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.


A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery

A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery PDF
Author: Taosheng Chen
Publisher: CRC Press
ISBN: 1420070517
Size: 33.17 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 291
View: 4157

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A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery

by Taosheng Chen, A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery Books available in PDF, EPUB, Mobi Format. Download A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery books, The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P


Cell Based Assays For High Throughput Screening

Cell Based Assays for High Throughput Screening PDF
Author: Paul A. Clemons
Publisher: Humana Press
ISBN: 9781603275446
Size: 22.69 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 218
View: 2244

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Cell Based Assays For High Throughput Screening

by Paul A. Clemons, Cell Based Assays For High Throughput Screening Books available in PDF, EPUB, Mobi Format. Download Cell Based Assays For High Throughput Screening books, As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.